Villin



Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).

3D Structures of Villin
Update June 2011

Supervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR

Villin
3fg7 – hVIL gelsolin domains 4-6

1unc – hVIL headpiece

3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata

2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken

1yu5, 1qqv - cVIL headpiece

3myc, 3mye, 3nkj - cVIL headpiece (mutant)

1vii, 2vik, 2vil - cVIL headpiece - NMR

2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR

2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic

Advillin
1und – hAVIL headpiece